Altogen
Biosystems is an international developer and laboratory for genetic research.
Laboratory offers and additional experiments include IC-50 assays, toxicology
assays, 28-day generation of stably-transfected cells, RNAi testing and more.
Dedicated to aiding pharmaceutical companies with cutting-edge and specialized
services, Altogen Biosystems ventures to optimize modern laboratory
discoveries. Visit the catalog of xenograft models for a Calu-6 xenograft model.
Vandetanib is a multikinase inhibitor that is a target of drug treatments for non-small cell lung cancer. In this study, researchers determine the cellular and biological effects of vandetanib on Calu-6 cells. Results showed that vandetanib inhibits Calu-6 cell migration and invasiveness. Vandetanib also induces autophagy in Calu-6 cells by increasing the level of reactive oxygen species (ROS). These findings show that vandetanib produces a double effect in some NSCLC cells, which presents vandetanib as a potential agent for treatment of Calu-6 cells. [ LINK ]
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