Lung cancer has posed a particular challenge to medical researchers; though there are patients that can serve as test subjects during clinical trials, such trials take months, if not years to complete. Such issues have been resolved through the advent of cell lines that accurately replicate those that would be found in tumors, and can react appropriately to introduced drugs and nucleic acid sequences. With the right transfection reagents, research investigating the role that genetic mechanisms play in cell proliferation can give accurate data that translates into valuable preclinical information. Calu-6 cells, which are epithelial lung cancer cells, were derived from human tissue, and are known for having been used to gauge the interaction between antimycin A and lung cancer, giving the medical field information regarding the effects of reactive oxygen species on cell apoptosis.
Vandetanib is a multikinase inhibitor that is a target of drug treatments for non-small cell lung cancer. In this study, researchers determine the cellular and biological effects of vandetanib on Calu-6 cells. Results showed that vandetanib inhibits Calu-6 cell migration and invasiveness. Vandetanib also induces autophagy in Calu-6 cells by increasing the level of reactive oxygen species (ROS). These findings show that vandetanib produces a double effect in some NSCLC cells, which presents vandetanib as a potential agent for treatment of Calu-6 cells. [ LINK ]
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