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Effect of Curcumin on Calu-6 Cells

Curcumin is an herbal compound that has been reported to decrease telomerase and gene expression and could be used to treat lung cancer. In this study, researchers analyze the effects of pure curcumin and curcumin-loaded NIPAAm-MAA nanoparticles on Calu-6 cells. Real-time PCR was used to measure telomerase and pinX1 gene expression. The PCR results revealed that curcumin decreased the expression of telomerase gene and the expression of pinX1 increased. An MTT assay revealed that curcumin-loaded NIPAAm-MAA inhibited the growth of Calu-6 cells in a dose-dependent manner. These findings revealed that both types of curcumin produced cytotoxic effects on Calu-6 cells through the down-regulation of telomerase and stimulation of pinX1 gene expression. [LINK]


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