Skip to main content

Effect of Curcumin on Calu-6 Cells

Curcumin is an herbal compound that has been reported to decrease telomerase and gene expression and could be used to treat lung cancer. In this study, researchers analyze the effects of pure curcumin and curcumin-loaded NIPAAm-MAA nanoparticles on Calu-6 cells. Real-time PCR was used to measure telomerase and pinX1 gene expression. The PCR results revealed that curcumin decreased the expression of telomerase gene and the expression of pinX1 increased. An MTT assay revealed that curcumin-loaded NIPAAm-MAA inhibited the growth of Calu-6 cells in a dose-dependent manner. These findings revealed that both types of curcumin produced cytotoxic effects on Calu-6 cells through the down-regulation of telomerase and stimulation of pinX1 gene expression. [LINK]


Comments

Post a Comment

Popular posts from this blog

Transfection and Xenograft Tools for Calu-6 From Altogen Biosystems

Altogen Biosystems is an international developer and laboratory for genetic research. Laboratory offers and additional experiments include IC-50 assays, toxicology assays, 28-day generation of stably-transfected cells, RNAi testing and more. Dedicated to aiding pharmaceutical companies with cutting-edge and specialized services, Altogen Biosystems ventures to optimize modern laboratory discoveries. Visit the catalog of xenograft models for a Calu-6 xenograft model .
Post a Comment
Read more

Calu-6 Cell Line

The Calu-6 cell line was established from the lung tissue of a 61-year-old Caucasian female who had been suffering from anaplastic carcinoma. Calu-6 cells are tumorigenic and have a modal chromosome number of 59. They also exhibit adherent cultural properties and display an epithelial morphology. The Calu-6 cell line is a suitable transfection host for in vivo and in vitro  methods to study lung cancer, and a Calu-6 Transfection Reagent  can be purchased through Altogen Biosystems  to transfect Calu-6 cells. A Calu-6 xenograft model can be found here . 
Post a Comment
Read more

The Role of Vandetanib in Calu-6 Cells

Vandetanib is a multikinase inhibitor that is a target of drug treatments for non-small cell lung cancer. In this study, researchers determine the cellular and biological effects of vandetanib on Calu-6 cells. Results showed that vandetanib inhibits Calu-6 cell migration and invasiveness. Vandetanib also induces autophagy in Calu-6 cells by increasing the level of reactive oxygen species (ROS). These findings show that vandetanib produces a double effect in some NSCLC cells, which presents vandetanib as a potential agent for treatment of Calu-6 cells. [ LINK ]
Post a Comment
Read more